摘要 目的：制备槐定碱分子印迹聚合物，研究槐定碱分子印迹聚合物的吸附性及体外释药特性。方法：用沉淀聚合法制备槐定碱分子印迹聚合物，分别用吸附动力学、静态吸附及平衡吸附试验对分子印迹聚合物进行吸附性研究；研究在不同溶剂介质中和不同pH条件下槐定碱分子印迹聚合物吸附性；考察人工胃液条件下槐定碱分子印迹聚合物体外释放特性。结果：吸附性试验表明MIPs对槐定碱具有明显的特异性吸附能力；溶液介质及pH对槐定碱分子印迹聚合物的吸附性有一定的影响；体外释放实验表明槐定碱分子印迹聚合物有缓释效果。结论：分子印迹聚合物可显著提高药物的生物利用度并具有缓释效果。

关键词： 分子印迹 槐定碱 体外释药 吸附性

Abstract  Objective: Preparation of sophoridine molecularly imprinted polymer, adsorption and release characteristics in vitro of sophoridine molecularly imprinted polymers. Methods: Preparation of molecularly imprinted polymers containing sophoridine by precipitation polymerization, and the molecular imprinted polymer adsorption study on adsorption kinetics, adsorption and equilibrium adsorption experiment; The molecularly imprinted polymer adsorption study on adsorption kinetics, adsorption and equilibrium adsorption experiment; Study on the effect of sophoridine molecularly imprinted polymer adsorption conditions in different solvents and different pH conditions; In vitro release test of sophoridine molecularly imprinted polymer drug release study. Results: Adsorption experiments show that MIPs has specific adsorption ability significantly of sophoridine; The solution medium and pH has some influence on the adsorption of sophoridine molecularly imprinted polymers; Pharmacokinetic experiments show that, compared with the raw material medicine, molecular imprinted polymer bioavailability significantly increased and sustained release effect preliminary. Conclusion: Significantly improve the bioavailability of drugs and has sustained release effect can be molecularly imprinted polymer.

Key words: Molecular imprinting  sophoridine  release in vitro  adsorption